The two men were detained in Latvia after "close cooperation" with US counterparts, LETA said, citing State Police spokeswoman Ilze Jurēvica.
The names of those detained and the exact nature of the accusations against them were not released. Investigations were reportedly ongoing.
Matters relating to their potential extradition to the US are being dealt with by the state prosecutor's office.
As previously reported by LSM, Latvian residents and Latvia-born individuals are on the US' wanted lists in connection with suspected cyber crimes, most notably Aleksey Belan (a Latvia-born Russian citizen) who is alleged to be part of a plot involving the Russian security service, the FSB; and Peteris Sahurovs, who has a $50,000 reward on his head and is wanted for wire fraud. Both are on the FBI's most wanted list.
The highest-profile case so far was that of Deniss Čalovskis, who was extradited and convicted in the US but returned to Latvia after serving his sentence.