The refugees arrived in Latvia late Wednesday and are now at Latvia's only asylum seeker center in Mucenieki.
Two of the families are from Syria, two from Iraq. Among them are skilled workers like a bank employee, a chef, a barber, and a tailor.
The Border Guard have already started processing their asylum applications and introduced them to their rights and obligations during the asylum procedure.
State and non-governmental organizations will start meeting with the families to assist their integration process.
Latvia has agreed to take in a total of 531 refugees from Italy and Greece within two years, with the possibility that number could rise to a maximum of 776 if agreement can be reached with other EU member states. The first two families arrived early February.