Dombrovskis told Latvian Radio that instability in financial markets was to be expected following the vote.
"However the question is whether this instability will have long-lasting consequences for the European economy and financial markets. As of now there are no direct indications [that would testify] to that," said Dombrovskis.
He said that different models of cooperation between the UK and the EU are possible - ones with or without direct access to the EU single market, and with or without free worker movement.
"The UK itself needs to make these decisions – exactly how they see future cooperation. The faster they make it clear, the less uncertainty and speculation there'll be," he said.
Replying to the question of whether the referendum outcome could influence the stability not only of the British pound but of the euro as well, he said that the current fall in currency value reflects worries in the financial markets.
"However I'll stress this again – at the moment there's no reason to think that these worries will have any lasting consequences," Dombrovskis said.
As reported, Dombrovskis recently took over the powers of Britain's EU Commissioner following Jonathan Hill's resignation from the post.
Dombrovskis told Latvian Radio that it was a surprise to him, and he had tried convincing Hill to remain in office.
"My goal here will be ensuring the inheritability of the jobs that have already been started," he said.
PM Māris Kučinskis is to present Latvia's official position on the UK exit talks at the European Council meeting starting Tuesday.
According to a Foreign Ministry statement, the Latvian Government will make every effort to protect its national interests, the interests of Latvian nationals in the UK and the EU’s common interests.