The private visit has involved Kerry passing a slide rule over Citadele bank - owned by a consortium of US investors - as well as meeting Prime Minister Maris Kucinskis March 21.
"During the meeting, both sides discussed global economic trends, as well as potential economic cooperation with the US," said a statement form the government press office.
Economic links in areas such as IT, food exports and financial services were discussed, it added.
"The Latvian government is ready to continue to work actively with the US attracting big investors. The Latvian Investment and Development Agency Representation opening in the US this year confirms the government's commitment in this regard," the statement said.
In an interview with the LETA news service, Kerry was quoted as saying Latvia was "a place where something is happening and the possibilities are real" as far as foreign investors are concerned.
However he did not disclose whether he would make any specific investments himself.