From 13 to 26 October the exercise, which also involves bomb disposal teams from fellow NATO member states Germany and Lithuania, will clear ground at the former Red Army munitions storage depot in Cekule.
On October 20, the mines recovered during the drills will be destroyed at the country's main Adazi military base.
Around 80 soldiers, many of them from Latvia's reserve force the Zemessardze, will participate with logistics support from the regular army.
Cekule ammunition depot is one of the largest remaining sites of unexploded ordnance, having been in military use since 1920.
In a similar exercise last year, Latvian and Swedish ordnance experts disposed of more than 1,000 explosive charges.